MOTS-c Research Peptide
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in the mitochondrial 12S rRNA gene, studied in AMPK and metabolic-regulation research.
3 listed MOTS-c presentations
Each presentation is a separate specification with its own product code. Open one to add it to your inquiry cart or to ask for a quote on WhatsApp. Pricing, availability and lot documents are confirmed for each order.
| Presentation | Per vial | Per box | Product code |
|---|---|---|---|
| MOTS-c 10 mg → | 10 mg | 10 vials | MS10 |
| MOTS-c 20 mg → | 20 mg | 10 vials | MS20 |
| MOTS-c 40 mg → | 40 mg | 10 vials | MS40 |
Amounts are per vial. mg, IU and mL describe different quantities and are not interchangeable. For laboratory research use only.
About MOTS-c
MOTS-c, the mitochondrial open reading frame of the 12S rRNA type-c, is a 16-amino-acid peptide, Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene. It was described in 2015 by Changhan Lee, Pinchas Cohen and colleagues at the University of Southern California.
Together with humanin, it is one of the best-studied mitochondrial-derived peptides: short peptides encoded in mitochondrial DNA that act as signals to the rest of the cell.
Research context
The original work reported that MOTS-c inhibits the folate cycle and de novo purine synthesis, leading to accumulation of the AMP mimic AICAR ribonucleotide and activation of AMPK. Later studies described its translocation to the nucleus under metabolic stress, where it influences gene expression.
It is used in research on skeletal-muscle glucose metabolism, AMPK signaling and physical capacity in aging mouse models.
What to confirm for MOTS-c
Check these points with our team before you order:
- Identity documentation confirming the 16-residue sequence.
- Net peptide content for this cationic peptide.
- The number of boxes you need and the US delivery destination.
- Which lot documents you require before ordering, such as an identity or purity report.
MOTS-c: frequently asked questions
How does MOTS-c relate to AICAR?
By inhibiting the folate cycle, MOTS-c causes the cell's own AICAR ribonucleotide (ZMP) to accumulate, which activates AMPK. The AICAR listed separately is the cell-permeable riboside that cells convert into the same ribonucleotide.
Why does the supplier sheet label these codes GHK-CU?
The name column of the supplier sheet shows GHK-CU for codes MS10, MS20 and MS40. Those codes are MOTS-c on the supplier's earlier list, and GHK-Cu is listed separately under its own codes, so they are published here as MOTS-c. Confirm the identity on the lot documents.
Which MOTS-c presentations are listed?
3 presentations are listed: 10 mg (MS10), 20 mg (MS20), 40 mg (MS40). Each is packed 10 vials per box, and every presentation has its own specification page and product code.
How do I request a quote for MOTS-c?
Open the presentation you need and use Ask price to message PureForm Biosciences on WhatsApp, or add several materials to the inquiry cart and send them together. Pricing, current availability and lot documents are confirmed in that conversation.
Related research materials
- Humanin →Mitochondrial-derived peptide encoded within mitochondrial DNA.
- SS-31 (Elamipretide) →Mitochondria-targeted tetrapeptide that associates with cardiolipin.
- AICAR →Cell-permeable nucleoside that activates AMP-activated protein kinase.
- NAD+ →Redox coenzyme and substrate for sirtuins and PARPs.
- 5-Amino-1MQ →Membrane-permeable small-molecule inhibitor of NNMT.
Research Use Only. MOTS-c is supplied strictly for laboratory research. It is not a drug, supplement or medical product and is not for human or veterinary consumption.