PE-22-28 Research Peptide
PE-22-28 is a seven-amino-acid analogue of spadin that blocks the TREK-1 potassium channel, studied in neuronal excitability and rodent behavior research.
2 listed PE-22-28 presentations
Each presentation is a separate specification with its own product code. Open one to add it to your inquiry cart or to ask for a quote on WhatsApp. Pricing, availability and lot documents are confirmed for each order.
| Presentation | Per vial | Per box | Product code |
|---|---|---|---|
| PE-22-28 5 mg → | 5 mg | 10 vials | PE5 |
| PE-22-28 10 mg → | 10 mg | 10 vials | PE10 |
Amounts are per vial. mg, IU and mL describe different quantities and are not interchangeable. For laboratory research use only.
About PE-22-28
Spadin is a peptide released from the propeptide of sortilin (NTSR3) that blocks TREK-1, a two-pore-domain potassium channel. PE-22-28 is a shortened analogue of spadin, designed from its degradation products, that keeps TREK-1 inhibition in a seven-residue sequence.
Published characterization reported stronger TREK-1 inhibition in vitro and longer stability than the parent peptide.
Research context
PE-22-28 is used in research on TREK-1 channel pharmacology, neuronal excitability and hippocampal neurogenesis, and in rodent behavioral paradigms.
What to confirm for PE-22-28
Check these points with our team before you order:
- Identity and net peptide content on the lot documents.
- The number of boxes you need and the US delivery destination.
- Which lot documents you require before ordering, such as an identity or purity report.
PE-22-28: frequently asked questions
What is TREK-1?
TREK-1 is a two-pore-domain potassium channel that helps set the resting potential of neurons. Spadin and its analogue PE-22-28 inhibit it.
Which PE-22-28 presentations are listed?
2 presentations are listed: 5 mg (PE5), 10 mg (PE10). Each is packed 10 vials per box, and every presentation has its own specification page and product code.
How do I request a quote for PE-22-28?
Open the presentation you need and use Ask price to message PureForm Biosciences on WhatsApp, or add several materials to the inquiry cart and send them together. Pricing, current availability and lot documents are confirmed in that conversation.
Related research materials
Research Use Only. PE-22-28 is supplied strictly for laboratory research. It is not a drug, supplement or medical product and is not for human or veterinary consumption.